Comparing & Contrasting the Different Myeloid Pathways for Functional Reprogramming to Identify Which Pathways are Better Targets
Time: 9:00 am
day: Pre-Conference Workshop Day
Details:
A comprehensive deep dive into the key molecular pathways, cell-surface receptors, intracellular regulators, and emerging targets involved in the reprogramming of myeloid cells. Rank different pathways by therapeutic potential, feasibility and safety, to ultimately improve and better identify functional reprogramming strategies.
- Review the major myeloid-targeted strategies being pursued to reprogram immune-suppressive cells (especially M2-like TAMs) into pro-inflammatory states, or pro-inflammatory ones back to immuno-regulatory/tolerant ones, depending on therapeutic needs
- Understand why some targets have failed and what lessons can be drawn
- Compare checkpoint-based targeting with broader metabolic, epigenetic, and transcriptional approaches
- Explore biomarker strategies for patient selection, disease staging, and response tracking
- Discuss, evaluate and compare emerging targets and combination therapies
Speakers:
