The Dual Role of Human Tumor-Associated Macrophages in Modulating Anti-Tumor Immune Responses in Lung Cancer

Time: 9:30 am
day: Conference Day Two

Details:

• TAMs do not conform to the classic M1/M2 classification, exhibiting a distinct and complex phenotype in human lung cancer
• TAMs are not purely suppressive; they exert a range of effects—both inhibitory and stimulatory, on tumor-specific T-cell responses
• TAM-derived PD-L1 plays a critical and nuanced role in modulating anti-tumor T-cell activity
• TAMs regulate NK cell responses and antibody efficacy, including through mechanisms like TAM-induced NK cell hypofunction and trogocytosis (both lethal and sublethal)

Speakers:

Evgeniy Eruslanov Evgeniy Eruslanov, PhD, is a Research Associate Professor in the Department of Surgery at the Perelman School of Medicine, University of Pennsylvania. He completed postdoctoral Read more